Innovation

Because we are constantly concerned with the efficiency of the product, we use the latest innovations in cosmetology. These include Aquaphyline®, Aldavine, Osmocide, Resveratrol, Plant stem cell extract, Glycans, Sytenol® A and others

Aquaphyline® – Aquaporins Hydration concept

The discovery of Aquaporins was awarded the Nobel Prize in2003. The very valuable research carried out by Dr. Gheorghe Benga, Professor of Molecular Biology at “Iuliu Hatieganu” University in Cluj, contributed significantly to this important discovery.

Aquaporin 3 (AQP3) are pathways located at the dermo-epidermal junction, adjusting water circulation between skin layers.

Aquaphyline®, Wild Pansy (Viola Tricolor) extract , has a powerful moisturizing effect, acting by way of a dual mechanism: stimulation of Aquaporin synthesis and increased Hyaluronic Acid synthesis, the skin’s well-known “molecular sponge.”

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Aquaphyline®

Stimulates the synthesis of AQP3 by 44%

In vitro study on human Keratinocyte culture, Aquaphyline® 0.5%

 

Aquaphyline® determines the increase in the quantity of Hyaluronic Acid by 23%**

In vitro study carried out on human Keratinocyte culture, Aquaphyline® 1%, with synthesized Hyaluronic Acid dosing, through specifically modified ELISA Test;

VINIFEROL ® (Resveratrol)

Viniferol® is a complex obtained from viniferina and resveratrol, extracted from grape-vine stems of Bordeaux, one of the most effective anti-wrinkle and anti-aging agents.

Viniferol deeply restructures and regenerates skin. His effect on cellular longevity was demonstrated based on the famous French-Paradox phenomenon. French, although having a diet rich in fat, show a low incidence of cardiovascular diseases due to regular consumption of red wine, rich in resveratrol.
Researchers at Harvard, studying populations of centenarians in Okinawa and Crete, discovered that they shared activated “longevity genes” called Sirtuins. Resveratrol has been shown to be one of the most potent Sirtuins activators, proving an anti-aging effect by delaying cellular aging.

 

VINIFEROL® significantly reduce wrinkles by Botox-like effect on the skin
Viniférol®, pure extract stem vine (10% e-Viniferine and a total of 50% Resveratrol oligomers) produces outstanding results on the prevention and reduction of wrinkles already installed thanks to botox-like effect – reduction muscle contraction that cause expression lines

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“The simple fact that there are genes that control
aging is really one of the most important discoveries in the last decade or more”

Dr David Sinclair, PhD, Harvard Medical School

“The discovery of Sirtuins is fundamental. It ushers in a new genetic aging control era”

Cosmetiquemag;dec 2008-ian 2009

PhytoCellTecTM AlpRose

PhytoCellTecTM Alp Rose is an extract from the plant stem cells of the Rhododendron ferrugineum, a perennial plant that grows at very high altitudes, exceeding 2000 m in the Alps, in extreme climate conditions: high temperature variations, UV, and dryness.

Obtained through biotechnology, plant stem cell extracts maintain the vitality and longevity of skin stem cells, stimulating epidermal regeneration; they restore the epidermal barrier function and delay the aging process.

The skin is visibly rejuvenated.

This new technology facilitates the obtaining of stem cells from plants, the fragmentation of the membrane and the incorporation of the content of the stem cell in liposomes to allow for deep penetration into the epidermis.

 

The effect of Alp Rose on the epidermal stem cell

In vitro study

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Method
  • Epidermal stem cells were divided into 4 lots. The 3rd and 4th lots were treated with Alp Rose stem cell extract.
  • The 2nd and 4th lots were radiated with UVA+ UVB at 450kj/m2.
  • Determination of colony-forming efficacy (CFE)

Results

  • CFE had values 75% higher when Alp Rose extract 0.15% was present
  • The increase remained the same even when subjected to UV radiation

Conclusions:

  • Alp Rose increases epidermal stem cell vitality
  • Alp Rose protects epidermal stem cells against UV stress

Alp Rose protects the skin against environmental aggressor factors: stress induced by solar radiation, cold, wind

Study performed on a lot of 22 volunteers, phenotype II, average age of 41, during a 16-day ski holiday in the Alps, at a high altitude.

Applications : 3 times/day on half of the face with:

  • Sun cream SPF 30 (placebo)
  • Sun cream SPF 30 and 0.4%PhytocellTec Alp Rose
  • Duration: 16 days

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PhytoCellTec Alp Rose increase the skin’s resistance to extreme environmental conditions:* UV, cold, wind, reducing transepidermal water loss (TEWL) by 42%.

In vivo study demonstrated that Alp Rose visibly improves skin’s appearance, lessens wrinkles, increases brightness, and reduces irritation due to extreme environmental conditions.

Results:

  • There was no improvement for any of the parameters on the half of the face treated with a placebo, and even a worsening of the wrinkles was reported.
  • On the half of the face treated with Alp Rose, the results showed an improvement in the skin’s look:
  • Wrinkles were less visible in 45% of the volunteers
  • Complexion was more radiant in 54% of the volunteers
  • Redness/irritation was reduced in 9% of the volunteers

Anti-Wrinkle effect: visible reduction in just 16 days in the depth and number of “crow’s feet” wrinkles

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day 1 – photos taken with a Visioface Quick device

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day 17 – After 16 days of treatment with 0.4% PhytoCellTec Alp Rose

Glykokine Factor STM

Glycans are complex polysaccharides of the skin. Their studies led to the emergence of a new science: Glycobiology

“We are in the throes of declaring the nobility of polysaccharides, and research on these fabulous molecules has only just begun, declared Gérard Redziniak, President of the International Federation of Societies of Cosmetic Chemists. President of IFSCC* Congress, Paris, 2014

Glycans are key components of the dermis, macromolecules that establish communication between skin cells. They are very well tolerated, as they occur naturally in the human body.
With age, their effectiveness is greatly diminished.

Glycobiotechnology is one of the most important current scientific trends in skin care.

Polysaccharides, obtained through Glycobiotechnology, help thin weakened and damaged skin to resist daily aggressors. Polysaccharides have entered the noble class of anti-aging molecules.

Glykokine Factor STM helps restore communication between skin cells and enables the transmission of messages to fibroblasts to produce collagen.
Glycokine Factor STM acts on Keratinocytes (epidermal cells), and induces chain reactions to fibroblasts in the dermis by stimulating the production of Hyaluronic  Acid, Laminin-5, and Elastin.
Skin regains its firmness, elasticity, and suppleness.

In just one month,  Glycokine Factor STM helps reduce the signs of premature aging

  • Skin regains its firmness, elasticity, and suppleness.
  • Significantly reduces the number of wrinkles
  • Restores the skin’s micro relief and improves its look
  • Hydrates
  • Increases the skin’s elasticity, giving it strength and resilience
  • Induces a feeling of comfort
  • Helps the skin fight the external aggressions

Before

After

Glycokine Factor STM stimulates the synthesis of Hyaluronic Acid

Evaluation of the synthesis of Hyaluronic Acid in human Keratinocyte cultures:

  • Normal human Keratinocytes (3% Glycine Factor STM) => + 40%, p <0.01
  • Skin grafts (1.5% Glycokine Factor STM) => + 55%, p <0.02

By stimulating the synthesis of Hyaluronic Acid, Glycokine Factor STM helps recreate the aqueous microenvironment for Keratinocytes

Sytenol® A

Sytenol® A is an innovate active ingredient with the same efficiency as topical retinoids in reducing acne symptoms (in vitro studies):

  • Reduces the sebum secretion through the inhibition of 5-alpha reductase
  • Exihibits an excellent antibacterial action (on P. acnes, Candida, Staphilococcus aureus)
  • Inhibits the pro-inflammatory enzymes acting at different levels of the inflammatory cascade.
  • Promotes a powerful inhibitory  action on Elastastes.

Sytenol® A has demonstrated excellent clinical efficiency in light, medium, and severe acne.

A clinical study on 60 patients with light  (<10 comedons), medium(10-25), severe acne (>25).

Evaluation at 2, 4 and 6 weeks, 2 applications/per day.

The study showed Sytenol® A efficacy by reducing with 58% the appearance of acne and the number of comedons.

Maximum efficiency was noticed after 4 and 6 weeks.

Sytenol® A is very well tolerated, and does not have the adverse effects of topical retinoids.

The value of the parameters in vitro demonstrates the superior efficiency of Sytenol® A

Values iC50 on P. acnes:

IC50 Sytenol® A  A=15.63 µg/ml

IC50 Retinol  31.25µg/ml

Minimun Inhibiting Concentration(CMI) values:

S.aureus  – 1µg/ml

epidermidis –2µg/ml

Candida  albicans  –1,5µg/ml

EcodermineTM 

EcodermineTM – delicately and specifically restores Saprophytic floraTOLERISKIN-DEMACHIANT-200-ML-300x450

EcodermineTM is a combination of glucides and lactose, with prebiotic type, selective action. It relies on the presence of enzymes that protect the skin’s ecosystem – normal flora (Saprophytic).

EcodermineTM fights skin problems related to microbial imbalance (i.e. intolerant, acne, dry, or itchy skin) helping the skin’s natural defense mechanisms.

Preserves and restores normal skin flora, protecting beneficial bacteria that exists naturally in the skin, to the detriment of pathogens, or “bad bacteria.”

Stimulates the effect of prebiotic flora in detriment of pathogens.

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